Publication list

Sat, 28 Mar 2026 00:00:00 +0000

Peer-reviewed articles

Hallet A, Oblasser C, Spineli LM, Groß MM. Transition from independent midwifery care to Early Prevention Network Services in Germany – A cross-sectional survey. BMC Health Serv Res 2026. doi: 10.1186/s12913-026-14414-4 PubMed

Spineli LM. Inconsistency was more prevalent than reported: an empirical study of 57 networks with multiple treatments using the node-splitting approach and a novel interpretation index. Syst Rev 2025; 14(1):240. PubMed

Spineli LM. The AMSTAR 2 publication lacks explicit instructions on how to assess the appropriateness of statistical methods (item 11) and publication bias (item 15), and does not reflect advances in meta-analysis. J Clin Epidemiol 2025; 188:111988. Epub ahead of print. PubMed

Spineli LM, García-Sierra AM, Yepes-Nuñez JJ. A database to initiate methodological advances in the evaluation of transitivity assumption in network meta-analysis: qualitative features and limitations of the tracenma R package. BMC Med Res Methodol 2025; 25(1):183. PubMed

Bertl K, Isik A, Truong T, Spineli LM, Heimel P, Manschiebel W, Stavropoulos A. Efficacy of Air Powder Water-Jet Devices in Cleaning Implant Surfaces in a Non-Surgical Peri-Implantitis Treatment Simulation-A Laboratory Study. Clin Oral Implants Res 2025; 36(9):1075-1085. PubMed

Stavropoulos A, Al Said A, Mustafa O, Spineli LM, Heimel P, Bertl K. Factors Affecting the Efficacy of Airflowing in Cleaning Implant Surfaces in a Surgical Peri-Implantitis Treatment Simulation-A Laboratory Study. Clin Oral Implants Res 2025; 36(9):1146-1158. PubMed

Spineli LM, Papadimitropoulou K, Kalyvas C. Exploring the Transitivity Assumption in Network Meta-Analysis: A Novel Approach and Its Implications. Stat Med 2025; 44(7):e70068. doi: 10.1002/sim.7006. PubMed

Tatas Z, Kyriakou E, Seehra J, Pandis N, Spineli LM. Statistical Heterogeneity in Oral Health Meta-Analyses. J Dent Res 2025; 104(5):481-488. PubMed

Spineli LM. An empirical study on 209 networks of treatments revealed intransitivity to be common and multiple statistical tests suboptimal to assess transitivity. BMC Med Res Methodol 2024; 24(1):301. PubMed

Spineli LM. Local inconsistency detection using the Kullback-Leibler divergence measure. Syst Rev 2024; 13(1):261. PubMed

Gehling H, Spineli LM, Gross MM. Investigating the associations between early labour onset symptoms and self-diagnosed labour onset in a cohort study of primiparas. Sex Reprod Healthc 2024; 42:101033. PubMed

Celetta E, Spineli LM, Avignon V, Gehling H, Gross MM. An exploratory review on the empirical evaluation of the quality of reporting and analyzing labor duration. Birth 2024; 51(4):773-782. PubMed

Mheissen S, Spineli LM, Daraqel B, Alsafadi AS. Language bias in orthodontic systematic reviews: A meta-epidemiological study. PLoS One 2024; 19(4):e0300881. PubMed

Spineli LM, Kalyvas C, Yepes-Nuñez JJ, García-Sierra AM, Rivera-Pinzón DC, Seide SE, Papadimitropoulou K. Low awareness of the transitivity assumption in complex networks of interventions: a systematic survey from 721 network meta-analyses. BMC Med 2024; 22(1):112. PubMed

Keratiotis G, Spineli L, De Bruyne MAA, De Moor RJG, Meire MA. A 22-year follow-up cross-sectional study on periapical health in relation to the quality of root canal treatment in a Belgian population. Int Endod J 2024; 57(5):533-548. PubMed

Sobootian DJ, Bronzlik P, Spineli LM, Becker LS, Winther HB, Bueltmann E. Convolutional Neural Network for Fully Automated Cerebellar Volumetry in Children in Comparison to Manual Segmentation and Developmental Trajectory of Cerebellar Volumes. Cerebellum 2023; 23(3):1074-1085. PubMed

Fasoulas A, Keratiotis G, Spineli LM, Pandis N, De Bruyne M, De Moor R, Meire M. Comparative efficacy of materials used in patients undergoing pulpotomy or direct pulp capping in carious teeth: A systematic review and meta-analysis. Clin Exp Dent Res 2023; 9(6):1129-1148. PubMed

Kalyvas C, Papadimitropoulou K, Malbecq W, Spineli LM. Dealing with censoring in a network meta-analysis of time-to-event data with fractional polynomials. Res Methods Med Health Sci 2024; 5(3):64–75. Journal

Spineli LM. Using network meta-analysis to predict the percentage of missing participants for a future trial. Res Methods Med Health Sci 2023; 4(4):140-149. Journal

Ferreira LAQ, Diniz IMA, Peixoto RTRDC, Gomes NA, Caneschi CS, Spineli LM, Martins CC. Efficacy of antiseptics and chemomechanical methods for dentin caries lesions: A systematic review with GRADE approach. Front Oral Health 2023; 4:1110634. eCollection 2023. PubMed

Vincent CM, Spineli LM, Barlow P, Gross MM. Unplanned visits and midwife-led antenatal care. Eur J Midwifery 2022; 6:72. PubMed

Spineli LM. A revised framework to evaluate the consistency assumption globally in a network of interventions. Med Decis Making 2022; 42(5):637-648. PubMed

Spineli LM, Kalyvas C, Papadimitropoulou K. How robust are findings of pairwise and network meta-analysis in the presence of missing participant outcome data? BMC Med 2021; 19(1):323. PubMed

Bialek-Waldmann JK, Domning S, Esser R, Glienke W, Mertens M, Aleksandrova K, Arseniev L, Kumar S, Schneider A, Koenig J, Theobald SJ, Tsay HC, Cornelius ADA, Bonifacius A, Eiz-Vesper B, Figueiredo C, Schaudien D, Talbot SR, Bleich A, Spineli LM, von Kaisenberg C, Clark C, Blasczyk R, Heuser M, Ganser A, Köhl U, Farzaneh F, Stripecke R. Induced dendritic cells co-expressing GM-CSF/IFN-α/tWT1 priming T and B cells and automated manufacturing to boost GvL. Mol Ther Methods Clin Dev 2021; 21:621-641. PubMed

Bertl K, Spineli LM, Mohandis K, Stavropoulos A. Root coverage stability: A systematic overview of controlled clinical trials with at least 5 years of follow-up. Clin Exp Dent Res 2021; 7(5):692-710. PubMed

Van der Mierden S, Spineli LM, Talbot SR, Yiannakou C, Zentrich E, Weegh N, Struve B, Zur Brügge TF, Bleich A, Leenaars CHC. Extracting data from graphs: A case-study on animal research with implications for meta-analyses. Res Synth Methods 2021; 12(6):701-710. PubMed

Spineli LM, Kalyvas C, Papadimitropoulou K. Quantifying the robustness of primary analysis results: A case study on missing outcome data in pairwise and network meta-analysis. Res Synth Methods 2021; 12(4):475-490. PubMed

Spineli LM, Papadimitropoulou K, Kalyvas C. Pattern-mixture model in network meta-analysis of binary missing outcome data: one-stage or two-stage approach? BMC Med Res Methodol 2021; 21(1):12. PubMed

Spineli LM, Kalyvas C, Papadimitropoulou K. Continuous(ly) missing outcome data in network meta-analysis: a one-stage pattern-mixture model approach. Stat Methods Med Res 2021; 30(4):958-975. PubMed

Stavropoulos A, Bertl K, Spineli LM, Sculean A, Cortellini P, Tonetti M. Medium and Long-Term Clinical Benefits of Periodontal Regenerative/Reconstructive Procedures in Intrabony Defects: Systematic Review and Network Meta-Analysis of Randomized Controlled Clinical Studies. J Clin Periodontol 2021; 48(3):410-430. PubMed

Gómez-Escobar LG, Mora-Ochoa H, Villanueva AV, Spineli LM, Sanclemente G, Couban R, García E, Chapman E, Yepes-Nuñez JJ. Effectiveness and adverse event of topical and allergen immunotherapy for atopic dermatitis: a systematic review and network meta-analysis protocol. Syst Rev 2020; 9(1):222. PubMed

Schick S, Spineli LM, Raio L, Groß MM. First assessed cervical dilatation: is it associated with oxytocin augmentation during labour? a retrospective cohort study in a university hospital in Switzerland. Midwifery 2020; 85:102683. PubMed

Spineli LM, Kalyvas C. Comparison of exclusion, imputation and modelling of missing binary outcome data in frequentist network meta-analysis. BMC Med Res Methodol 2020; 20(1):48. PubMed

Buckley BS, Sanders CD, Spineli L, Deng Q, Kwong JS. Conservative interventions for treating functional daytime urinary incontinence in children. Cochrane Database Syst Rev 2019; 9:CD012367. PubMed

Spineli LM, Kalyvas C, Pateras K. Participants’ outcomes gone missing within a network of interventions: Bayesian modeling strategies. Stat Med 2019; 38(20):3861-3879. PubMed

Spineli LM. An empirical comparison of Bayesian modelling strategies for missing binary outcome data in network meta-analysis. BMC Med Res Methodol 2019; 19(1):86. PubMed

Theobald SJ, Khailaie S, Meyer-Hermann M, Volk V, Olbrich H, Danisch S, Gerasch L, Schneider A, Sinzger C, Schaudien D, Lienenklaus S, Riese P, Guzman CA, Figueiredo C, von Kaisenberg C, Spineli LM, Glaesener S, Meyer-Bahlburg A, Ganser A, Schmitt M, Mach M, Messerle M, Stripecke R. Signatures of T and B Cell Development, Functional Responses and PD-1 Upregulation After HCMV Latent Infections and Reactivations in Nod.Rag.Gamma Mice Humanized With Cord Blood CD34+ Cells. Front Immunol 2018; 9:2734. PubMed

Mitroiu M, Rengerink KO, Pontes C, Sancho A, Vives R, Pesiou S, Fontanet JM, Torres F, Nikolakopoulos S, Pateras K, Rosenkranz G, Posch M, Urach S, Ristl R, Koch A, Spineli LM, van der Lee JH, Roes KCB. Applicability and added value of novel methods to improve drug development in rare diseases. Orphanet J Rare Dis 2018; 13(1):200. PubMed

Spineli LM, Yepes-Nuñez JJ, Schünemann HJ. A systematic survey shows that reporting and handling of missing outcome data in networks of interventions is poor. BMC Med Res Methodol 2018; 18(1):115. PubMed

Spineli LM. Modeling missing binary outcome data while preserving transitivity assumption yielded more credible network meta-analysis results. J Clin Epidemiol 2019; 105:19-26. PubMed

Weckend MJ, Spineli LM, Grylka-Baeschlin S, Groß MM. Association between increased antenatal vaginal pH and preterm birth rate: a systematic review. J Perinat Med 2019; 47(2):142-151. PubMed

Bültmann E, Spineli L, Hartmann H, Sander A, Lanfermann H. Quantitative microstructural cerebral changes in neurofibromatosis type 1. Brain Dev 2018; 40(5):376-382. PubMed

Volk V, Reppas AI, Robert P, Spineli LM, Sundarasetty BS, Theobald SJ, Schneider A, Gerasch L, Deves-Roth C, Klöß S, Koehl U, von Kaisenberg C, Figueiredo C, Hatzikirou H, Meyer-Hermann M, Stripecke R. Multidimensional Analysis Integrating Human T-Cell Signatures in Lymphatic Tissues with Sex of Humanized Mice for Prediction of Responses after Dendritic Cell Immunization. Front Immunol 2017; 8:1709. PubMed

Spineli LM. Missing binary data extraction challenges from Cochrane Reviews in mental health and implications on the empirical research. Res Synth Methods 2017; 8(4):514-525. PubMed

Bültmann E, Spineli LM, Göhner F, Hartmann H, Lanfermann H. Age-Related T2 Relaxation Times at 3 Tesla as biomarker of infratentorial brain maturation. Childs Nerv Syst 2018; 34(1):117-127. PubMed

Spineli LM, Jenz E, Großhennig A, Koch A. Critical appraisal of arguments for the delayed-start design proposed as alternative to the parallel-group randomized clinical trial design in the field of rare disease. Orphanet J Rare Dis 2017; 12(1):140. PubMed

Bültmann E, Spineli LM, Hartmann H, Lanfermann H. Measuring in vivo cerebral maturation using age-related T2 Relaxation Times at 3T. Brain Dev 2018; 40(2):85-93. PubMed

Oehrlich NE, Spineli LM, Papendorf F, Park-Simon TW. Clinical outcome of brain metastases differs significantly among breast cancer subtypes. Oncol Lett 2017; 14(1):194-200. PubMed

Sundarasetty B, Volk V, Theobald SJ, Rittinghausen S, Schaudien D, Neuhaus V, Figueiredo C, Schneider A, Gerasch L, Mucci A, Moritz T, von Kaisenberg C, Spineli LM, Sewald K, Braun A, Weigt H, Ganser A, Stripecke R. Human Effector Memory T Helper Cells Engage with Mouse Macrophages and Cause Graft-versus-Host-Like Pathology in Skin of Humanized Mice Used in a Nonclinical Immunization Study. Am J Pathol 2017; 187(6):1380-1398. PubMed

Volk V, Schneider A, Spineli LM, Grosshennig A, Stripecke R. The gender gap: discrepant human T-cell reconstitution after cord blood stem cell transplantation in humanized female and male mice. Bone Marrow Transplant 2016; 51(4):596-7. PubMed

Paparoupa M, Spineli L, Framke T, Ho H, Schuppert F, Gillissen A. Pulmonary Embolism in Pneumonia: Still a Diagnostic Challenge? Results of a Case-Control Study in 100 Patients. Dis Markers 2016; 2016:8682506. PubMed

Dressler N, Chandra A, Aguirre Davila L, Spineli LM, Schippert C, von Versen-Höynck F. BMI and season are associated with vitamin D deficiency in women with impaired fertility: a two-centre analysis. Arch Gynecol Obstet 2016; 293(4):907-14. PubMed

Koletsi D, Spineli LM, Lempesi E, Pandis N. Risk of bias and magnitude of effect in orthodontic randomized controlled trials: a meta-epidemiological review. Eur J Orthod 2015; 38(3):308-12. PubMed

Spineli LM, Pandis N, Salanti G. Reporting and handling missing outcome data in mental health: a systematic review of Cochrane systematic reviews and meta-analyses. Res Synth Methods 2015; 6(2):175-87. PubMed

Spineli LM, Fleming PS, Pandis N. Addressing missing participant outcome data in dental clinical trials. J Dent 2015; 43(6):605-618. PubMed

Huhn M, Tardy M, Spineli LM, Kissling W, Förstl H, Pitschel-Walz G, Davis J, Leucht S. Efficacy of pharmacotherapy and psychotherapy for adult psychiatric disorders: a systematic overview of meta-analyses. JAMA Psychiatry 2014; 71(6):706-15. PubMed

Samara MT, Spineli LM, Furukawa T, Engel R, Davis JM, Salanti G, Leucht S. Imputation of responder rates from means and standard deviations in schizophrenia. Schizophr Res 2013; 151(1-3):209-14. PubMed

Leucht S, Cipriani A, Spineli LM, Mavridis D, Örey D, Richter F, Samara M, Barbui C, Engel RR, Geddes JR, Kissling W, Stapf MP, Lässig B, Salanti G, Davis JM. Comparative efficacy and tolerability of 15 antipsychotic drugs in schizophrenia: a multiple-treatments meta-analysis. Lancet 2013; 382(9896):951-62. PubMed

Spineli LM, Leucht S, Cipriani A, Higgins JP, Salanti G. The impact of trial characteristics on premature discontinuation of antipsychotics in schizophrenia. Eur Neuropsychopharmacol 2013; 23(9):1010-6. PubMed

Spineli LM, Higgins JP, Cipriani A, Leucht S, Salanti G. Evaluating the impact of imputations for missing participants outcome data in network meta-analysis. Clin Trials 2013; 10(3):378-88. PubMed

Cipriani A, Barbui C, Salanti G, Rendell J, Brown R, Stockton S, Purgato M, Spineli LM, Goodwin GM, Geddes JR. Comparative efficacy and acceptability of antimanic drugs in acute mania: a multiple-treatments meta-analysis. Lancet 2011; 378(9799):1306-15. PubMed

Editorials

Tu YK, Pandis N, Spineli LM. Individual patient data meta-analysis: An example. Am J Orthod Dentofacial Orthop 2023; 166(6):619-623. PubMed

Spineli LM, Pandis N. Two-stage vs one-stage meta-analysis. Am J Orthod Dentofacial Orthop 2023; 166(3):295-298. PubMed

Spineli LM, Pandis N. An Introduction to Interpreting Meta-analyses for Orthodontists. Semin Orthod 2024; 30(1):50-57. Journal

Spineli LM, Pandis N. Meta-analysis of split-mouth studies. Am J Orthod Dentofacial Orthop 2023; 163(3):445-448. PubMed

Spineli LM, Pandis N. Meta-analysis of cluster-randomized trials. Am J Orthod Dentofacial Orthop 2023; 163(2):288-291. PubMed

Mheissen S, Spineli LM. Is there a difference among different bonded retainers in regard to survival rate? Evid Based Dent 2022; 23(4):156-157. PubMed

Spineli LM, Pandis N. An introduction to cumulative meta-analysis. Am J Orthod Dentofacial Orthop 2022; 161(3):474-476. PubMed

Spineli LM, Pandis N. Missing participant outcome data in meta-analysis. Part 2. Am J Orthod Dentofacial Orthop 2021; 160(4):632-635. PubMed

Spineli LM, Pandis N. Missing participant outcome data in meta-analysis. Part 1. Am J Orthod Dentofacial Orthop 2021; 160(3):481-483. PubMed

Spineli LM, Pandis N. Individual participant data in meta-analysis. Am J Orthod Dentofacial Orthop 2021; 159(6):868-870. PubMed

Spineli LM, Pandis N. Publication bias: Graphical and statistical methods. Am J Orthod Dentofacial Orthop 2021; 159(2):248-251. PubMed

Spineli LM, Pandis N. Reporting bias: Notion, many faces and implication. Am J Orthod Dentofacial Orthop 2021; 159(1):136-138. PubMed

Spineli LM, Pandis N. Problems and pitfalls in subgroup analysis and meta-regression. Am J Orthod Dentofacial Orthop 2020; 158(6):901-904. PubMed

Spineli LM, Pandis N. Fixed-effect versus random-effects model in meta-regression analysis. Am J Orthod Dentofacial Orthop 2020; 158(5):770-772. PubMed

Spineli LM, Pandis N. Exploring heterogeneity in meta-analysis: Meta-regression analysis. Am J Orthod Dentofacial Orthop 2020; 158(4):623-625. PubMed

Spineli LM, Pandis N. Exploring heterogeneity in meta-analysis: Subgroup analysis. Part 2. Am J Orthod Dentofacial Orthop 2020; 158(3):462-463. PubMed

Spineli LM, Pandis N. Exploring heterogeneity in meta-analysis: Subgroup analysis. Part 1. Am J Orthod Dentofacial Orthop 2020; 158(2):302-304.e1. PubMed

Spineli LM, Pandis N. Statistical heterogeneity: Notion and estimation in meta-Analysis. Am J Orthod Dentofacial Orthop 2020; 157(6):856-859.e2. PubMed

Spineli LM, Pandis N. Prediction interval in random-effects meta-Analysis. Am J Orthod Dentofacial Orthop 2020; 157(4):586-588. PubMed

Spineli LM, Pandis N. The importance of careful selection between fixed-effect and random-effects models. Am J Orthod Dentofacial Orthop 2020; 157(3):432-433. PubMed

Spineli LM, Pandis N. Meta-analysis: Random-effects model. Am J Orthod Dentofacial Orthop 2020; 157(2):280-282. PubMed

Spineli LM, Pandis N. Meta-analysis: Fixed-effect model. Am J Orthod Dentofacial Orthop 2020; 157(1):134-137. PubMed

Pandis N, Spineli LM. Die Netzwerk-Metaanalyse in der Kieferorthopädie: Die nächste Ebene der Evidenzsynthese? Inf Orthod Kieferorthop 2015; 47(1):57-59. Thieme

Pandis N, Fleming PS, Spineli LM, Salanti G. Initial orthodontic alignment effectiveness with self-ligating and conventional appliances: a network meta-analysis in practice. Am J Orthod Dentofacial Orthop 2014; 145(4 Suppl):S152-63. PubMed

Other publications

Thomas AM, Spineli LM, Gross MM, Zinsser LA. Die vaginale Untersuchung während der Geburt durch Hebammen in der Deutschschweiz. Obstetrica 2026 Source

Book chapters

Spineli LM. Meta-analysis and handling of missing data. In Pandis N. Biostatistics in Orthodontics. Design, analysis, reporting and synthesis of clinical studies. Zahnmedizinische Kliniken der Universität Bern. 2014. (Updated 2019)

Published statistical packages

Spineli LM. tracenma: Database for Developing Transitivity Methodology in Network Meta-Analysis. R package version 0.1.1. 2025. https://CRAN.R-project.org/package=tracenma [creator and maintainer]. GitHub development version in https://github.com/LoukiaSpin/tracenma